Installation hung up here:

Failed to copy hotfix files:C:\Users\itsm-sse-svc-cf\331588.tmp\dist\cfusion
                          Status: FATAL ERROR
                          Additional Notes: FATAL ERROR - Failed to copy the hotfix files to the target location:E:\ColdFusion10\cfusion
                                            FATAL ERROR - E:\ColdFusion10\cfusion\bin\coldfusion.exe (The process cannot access the file because it is being used by another process)

Tried several times, making sure all services were stopped, but no luck.

But uninstaller won't work either.

All coldfusion pages get this error:

Service Temporary Unavailable!

The server is temporarily unable to service your request due to maintenance downtime or capacity problems. Please try again later.

  Jakarta/ISAPI/isapi_redirector/1.2.32 ()

If I try an html page on the server, though, it works.

I did recreate the connectors afterward.

I guess we will try and reinstall CF10 really, really frustrating.  Thankfully it was on our dev server, not live.  Will not install this update on live until it's fixed....